ea0042p7 | (1) | Androgens2016
Merkel Olaf
, Aksoy Osman
, Suzani Martin
, Hassler Melanie
, Schlangen Karin
, Balber Theresa
, Mitterhauser Markus
, Moazzami Ali
, Schlederer Michaela
, Turner Suzanne
, Egger Gerda
, Hormann Gregor
, Hacker Markus
, Culig Zoran
, Pencik Jan
, Kenner Lukas
Prostate cancer (PCa) is the most frequent cancer in men in the western world. PCa growth is highly dependent on androgens and androgen ablation is the cornerstone of current therapeutic approaches. μ-Crystalline (CRYM) is the main component of the kangaroohs eyes lens. CRYM binds thyroid hormone (T3) in a NADPH dependent manner thereby sequestering it from being transcriptionally active in the nucleus. The role of CRYM in prostate cancer is largely unknown. This st...